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The causal role of opioids from the medical syndrome of hypogonadism is unknown as the several professional medical, Bodily, Life-style, and psychological stressors which will affect gonadal hormone stages haven't been sufficiently controlled for in scientific studies done to this point [see Adverse Reactions (6)].
5.17 Bone-Marrow Depression Promethazine HCl and codeine phosphate oral Resolution ought to be employed with caution in clients with bone-marrow melancholy. Leukopenia and agranulocytosis are described, normally when promethazine has been Employed in Affiliation with other identified marrow-toxic brokers.
Codeine is understood for being substantially excreted from the kidney, and the risk of adverse reactions to this drug could possibly be greater in clients with impaired renal perform.
Nonetheless, this impact is not steady and may be offset by an increased rate of cervical dilation, which tends to shorten labor. Check neonates exposed to opioids during labor for indications of surplus sedation and respiratory depression.
Steer clear of using promethazine HCl and codeine phosphate oral Option in adolescents 12 to 18 many years of age who have other risk factors which will improve their sensitivity on the respiratory depressant outcomes of codeine.
Make use of other supportive steps (such as oxygen and vasopressors) from the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require Sophisticated life-help approaches. Gastric emptying could possibly be useful in getting rid get more info of unabsorbed drug.
5.eight Pursuits Demanding Mental Alertness: Hazards of Driving or Operating Equipment Codeine and promethazine, two of your Lively components in promethazine HCl and codeine phosphate oral Option, may produce marked drowsiness and impair the mental and/or Actual physical talents necessary with the effectiveness of probably hazardous tasks including driving a vehicle or running machinery.
Promethazine HCl and codeine phosphate oral Resolution isn't recommended for use in pregnant Gals [see Use in Precise Populations (eight.1)]. Extended usage of promethazine HCl and codeine phosphate oral Answer for the duration of pregnancy may end up in neonatal opioid withdrawal syndrome, which may be daily life-threatening if not acknowledged and taken care of, and involves administration In keeping with protocols made by neonatology industry experts.
Location the combination in a container such as a sealed plastic bag and throw it away from the house trash. You can even adhere to your point out or neighborhood rules on how to properly toss away Promethazine Hydrochloride and Codeine Phosphate Oral Answer.
Inspite of this, Kann pointed out the lack of Akorn Prescription drugs may well cause drug shortages if other generic brands can't satisfy the demands from the consumers who were Formerly addressed with prescription drugs prepared by Akorn.
It's soluble in h2o and freely soluble in alcohol. The molecular fat is 320.88. Its molecular components is C17H20N2S•HCl, and it's got the subsequent chemical structure.
Minimal hypertension. A unexpected drop in blood pressure level can come about in lots of people in the course of cure with Promethazine Hydrochloride and Codeine Phosphate Oral Resolution which might induce you to feel dizzy, faint, lightheaded, or weak, particularly when you rise up (orthostatic hypotension). Your chance of getting this issue may be amplified if you take Promethazine Hydrochloride and Codeine Phosphate Oral Remedy with certain other medicines that lessen blood pressure.
7.8 Diuretics Opioids can lessen the efficacy of diuretics by inducing the discharge of antidiuretic hormone. Watch clients for indications of diminished diuresis and/or effects on hypertension and boost the dosage with the diuretic as desired.